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Overview of Diseases for Which CBD May Have Therapeutic Benefits
Source: Pisanti et al (2017)
Antinflammatory, antioxidant, antiapoptotic in in vitro and in vivo models of Aβ-evoked neuroinflammatory and neurodegenerative responses.
"Attenuation of the dopaminergic impairment in vivo; neuroprotection; improvement of psychiatric rating and reduction of agitation, nightmare
and aggressive behaviour in patients."
Improved signs of EAE in mice, antinflammatory and immunomodulatory properties.
Neuroprotective and antioxidant in mice transgenic models; no significant clinically important differences in patients.
Short term neuroprotective effects; inhibition of excitotoxicity, oxidative stress and inflammation in vitro and in rodent models.
Analgesic effect in patients with neuropathic pain resistant to other
Attenuation of the behavioural and glial changes in animal models of
schizophrenia; anti-psychotic properties on ketamine-induced symptoms
Reduction of muscular tension, restlessness, fatigue, problems in concentration, improvement of social interactions in rodent models of anxiety and stress; reduced social anxiety in patients.
Anti-depressant effect in genetic rodent model of depression.
Antiproliferative and anti-invasive actions in a large range of cancer types;
induction of autophagy-mediated cancer cell death; chemopreventive effects.
Suppression of nausea and conditioned gaping in rats
Antinflammatory properties in several in vitro and in vivo models; inhibition of inflammatory cytokines and pathways.
Inhibition of TNF-α in an animal model
Activity against methicillin-resistant Staphylococcus aureus
Inhibition of macrophage recruitment and TNF-α secretion in vivo and ex vivo; reduction in disease activity index in Crohn's patients.
Reduced infarct size through anti-oxidant and anti-inflammatory properties in vitro and in vivo.
Attenuation of fibrosis and myocardial dysfunction